Description:Mouse monoclonal antibody against tyrosine699 phosphorylated human signal transducer and activator of transcription 5b (p-STAT5b)
Purification:Protein G affinity purified
Product Type:Primary antibody
Target Protein:Tyrosine699 phosphorylated human STAT5b
Immunogen:A tyrosine699 phosphorylated human STAT5b peptide fragment conjugated with KLH.
Fusion Myeloma:Sp2/0-Ag14
Specificity:Reactive to tyrosine699 phosphorylated human STAT5b peptide fragment conjugated with KLH or the peptide-BSA conjugate, but not reactive to un-conjugated KLH or BSA.
Species Reacitvity:Human, others not tested
Host / Isotype: Mouse, IgG2b Kappa
Formulation:Lyophilized form from a solution of 0.01M PBS, pH7.0
Reconstitution: Double distilled water is recommended to adjust the final concentration to 1.00mg/mL.
Storage:Store at -20oC. Avoid freeze and thaw cycles.
Research Area:Signal transduction, gene transcription
Background:
Stat5b is a transcription factor that is activated in response to extra-cellular stimuli including IL-2, IL-4, MCSF and a variety of growth factors. In the process, receptor associated kinases phosphorylate Stat5b. Stat5b, then, forms dimers and translocates to nucleus. Inside nucleus, Stat5b binds to the promoter region on various genes to regulate biological processes such as apoptosis, T cell receptor signalling, and adult mammary gland development. Fusion of Stat5b to retinoic acid receptor-alpha (RARα) gene was identified in a small subgroup of acute promyelocytic leukemia patients.
Application:
In indirect ELISA, the antibody is reactive to tyrosine699 phosphorlylated humanSTAT5b peptide fragment conjugated with KLH or the peptide-BSA conjugate. The conjugates were coated to ELISA plate at 1μg/ml in pH 9.5 carbonate buffer.
Other applications have not been evaluated.
References:
If research is published using this product, please inform Anogen in order to cite the reference on this datasheet. Anogen will provide one unit of product in the same category as gratitude.
Product Specificity | mAb anti-Human Phospho-STAT5b [p-Y699], A2H6 |
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Application | EIA |
Size | 0.1 mg |
Anogen-Yes Biotech Laboratories Ltd.是一家位于加拿大密西沙加的生物技术公司。成立于1989年,我们30年来一直是高质量抗体基产品的骄傲供应商。我们提供300多种单克隆和多克隆抗体,以及60多种类型的ELISA试剂盒,用于研究,诊断和治疗应用。
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