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yesbiotech/mAb anti-Human IL-8, I8-61/0.1 mg/MO-C40017E

yesbiotech/mAb anti-Human IL-8, I8-61/0.1 mg/MO-C40017E
  • yesbiotech/mAb anti-Human IL-8, I8-61/0.1 mg/MO-C40017E
商品介绍
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Description

Details

Description:Mouse monoclonal antibody to human interleukin 8 (IL-8)

Purification: Protein G affinity purified

Product Type:Primary antibody

Target Protein:Human IL-8

Immunogen:Purified recombinant human IL-8

Fusion Myeloma:P3X63Ag8.653

Specificity:This antibody recognizes both recombinant and native human IL-8.

Species Reactivity: Human, others not tested.

Cross-reactivity:This antibody does not cross react with human Monocyte Chemotactic Activating Factor (MCAF) or RANTES (Regulated on Activation, Normal T-cell Expressed, and Secreted).

Host / Isotype: Mouse, IgG1 Kappa

Formulation: Lyophilized in 0.01M PBS, pH 7.0.

Reconstitution:Double distilled water is recommended and to adjust the final concentration to 1.00 mg/mL.

Storage: Store at -20oC

Research Area:Cytokine, interleukin and chemotaxis

Background:

Interleukin 8 (IL-8), like IL-6, is secreted by macrophages and a variety of cells that express Toll-like receptors in response to the stimulation of pathogens. IL-8"s primary function is to recruit neutrophils and other target cells through chemotaxis to the infected site to eliminate pathogens. IL-8 causes increased intracellular Ca2+, release of reactive oxygen species, and other physiological changes required for migration and phagocytosis. IL-8 is also known to promote angiogenesis.

Applications:

ELISA: React with human IL-8.

Neutralizing: In chemotaxis assay, the antibody inhibited 97 % of the chemotactic activity of IL-8 on RB/293 cell using 5mg/ml of MAb and 10ng/ml of human IL-8 in assay. This antibody inhibited the chemotactic effect of human IL-8, and had no inhibitory effect to MIP 1-bata and RANTES in neutrophil chemotaxis assay, indicating that the neutralizing activity is specific. The antibody also neutralized IL-8 induced calcium influx in human granulocytes.

Western Blot: The antibody when used at 0.02-0.1mg/ml concentration, will allow visualization of 100ng/lane of recombinant human IL-8. Figure (see image): Western blot analysis of recombinant human IL-8 using clone I8-61.

References:

If research is published using this product, please inform Anogen in order to cite the reference on this datasheet. Anogen will provide one unit of product in the same category as gratitude.

Additional

Additional Information

Product SpecificitymAb anti-Human IL-8, I8-61
ApplicationEIA, NT, WB
Size0.1 mg
品牌介绍

Anogen-Yes Biotech Laboratories Ltd.是一家位于加拿大密西沙加的生物技术公司。成立于1989年,我们30年来一直是高质量抗体基产品的骄傲供应商。我们提供300多种单克隆和多克隆抗体,以及60多种类型的ELISA试剂盒,用于研究,诊断和治疗应用。


作为一家专注于研究的公司,我们还开发了许多专有的诊断和治疗产品。我们的产品Abcream是一种有效的抗牛皮癣局部抗IL-8(CXCL8)单克隆抗体,已于2001年获得中国国家食品药品监督管理局(SFDA)的批准,并获得多项国际专利。我们的用于诊断目的的新生儿TSH ELISA试剂盒也已获得加拿大卫生部的许可。我们还启动了针对炎症,阿尔茨海默氏病和癌症的研究和开发产品。


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