Description:Mouse monoclonal antibody to human HLA-ABC (Class I HLA heavy chain).

Purification:Protein G affinity purified

Product Type:Primary antibody

Target Protein:Human HLA-ABC (Class I HLA heavy chain)

Immunogen:Purified class I HLA complex

Fusion Myeloma:Sp2/0-Ag14

Specificity:This monoclonal antibody reacts with human HLA-ABC.

Species Reactivity:Human, others not tested.

Host / Isotype:Mouse, IgG1 Kappa

Formulation:Lyophilized from a solution in 0.01M PBS, pH 7.2

Reconstitution:Double distilled water is recommended to reconstitute the antibody.

Storage: Store at -20^oC

Research Area:Haematology, Immunology

Background:

Human leukocyte antigen (HLA) is the antigen binding, membrane bound a chain of major histocompatibility complex I (MHC1). While the small b chain is the invariable beta 2 microglobulin, the a chain has three major isoforms (HLA-A, HLA-B, HLA-C) that are encoding by different loci on chromosome 6 and each of the isoforms has a highly variable region that resembles Fab on immunoglobulin. The HLA-ABC antibody reacts with a common epitope shared by HLA-A, HLA-B and HLA-C.

Application:

Western Blot

Immuno-precipitation

Immunohistochemistry (IHC)

Immunofluorescence

References:

Bushkin, Y., et. al. A New HLA-Linked T Cell Membrane Molecule, Related to the β Chain of the Clonotypic Receptor, is associated with T3. J. Exp. Med. (1986), 164(August):458-473.

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