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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
yesbiotech/pAb Rabbit anti-Phospho-Bcl-2 (Thr56)/0.1 mg/AI70003B
产品编号:AI70003B
市  场 价:¥4500.00
场      地:美国(厂家直采)
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$225.00
品      牌: yesbiotech
公      司:yesbiotech
公司分类:
yesbiotech/pAb Rabbit anti-Phospho-Bcl-2 (Thr56)/0.1 mg/AI70003B
商品介绍
  • Description
  • Additional

Description

Details

Description:Rabbit anti-Threonine 56 phosphorylated Bcl-2 polyclonal antibody

Purification: Protein G affinity purified

Product Type:Primary antibody

Target Protein:Threonine 56 phosphorylatedBcl-2

Immunogen:A synthetic peptide (SQPGHTpPHPASR) derived from human Bcl-2, conjugated with KLH for immunization

Specificity:This antibody is reactive to the above synthetic peptide derived from human Bcl2.

Species Reacitvity:Human and other species with consensus Bcl-2 sequence (SQPGHTpPHPASR)

Source:Rabbit

Formulation:Lyophilized in pH 7.4, 0.01M PBS

Reconstitution:Double distilled water is recommended to adjust the final concentration to 1.00mg/mL.

Storage:Store at -20oC

Research Area:Life science research, apoptotic signalling pathway

Background:

Bcl-2 is a 25kD inner mitochondrial membrane protein with anti-apoptotic function. It is believed that Bcl-2 suppresses apoptosis by inhibiting mitochondrial cytochrome C release, blocking caspase cascade and regulating mitochondrial calcium homeostasis. Bcl-2 is identified from the study of B-cell lymphoma. About 90% of follicular lymphoma is caused by Bcl-2 over-expression resulted from the translocation of Bcl-2 gene from chromosome 18 to the immunoglobulin heavy chain enhancer on chromosome 14. Bcl-2 is also involved with other malignancies such as melanoma, breast cancer, prostate cancer and lung cancer. Bcl-2 Thr56 phosphorylation by p38 MAPK results in cytochrome C release. Mutation near Thr56 aborted Bcl-2 anti-apoptotic function.

Application:

ELISA:React with synthetic peptide (SQPGHTpPHPASR) coated plate.

Other applications have not been evaluated.

References:

If research is published using this product, please inform Anogen in order to cite the reference on this datasheet. Anogen will provide one unit of product in the same category as gratitude.

Additional

Additional Information

Product SpecificitypAb Rabbit anti-Phospho-Bcl-2 (Thr56)
ApplicationWB, EIA
Size0.1 mg
品牌介绍

Anogen-Yes Biotech Laboratories Ltd.是一家位于加拿大密西沙加的生物技术公司。成立于1989年,我们30年来一直是高质量抗体基产品的骄傲供应商。我们提供300多种单克隆和多克隆抗体,以及60多种类型的ELISA试剂盒,用于研究,诊断和治疗应用。


作为一家专注于研究的公司,我们还开发了许多专有的诊断和治疗产品。我们的产品Abcream是一种有效的抗牛皮癣局部抗IL-8(CXCL8)单克隆抗体,已于2001年获得中国国家食品药品监督管理局(SFDA)的批准,并获得多项国际专利。我们的用于诊断目的的新生儿TSH ELISA试剂盒也已获得加拿大卫生部的许可。我们还启动了针对炎症,阿尔茨海默氏病和癌症的研究和开发产品。


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