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yesbiotech/pAb Rabbit anti-Human FPRL-1 C-terminal/0.1 mg/AI70001B

yesbiotech/pAb Rabbit anti-Human FPRL-1 C-terminal/0.1 mg/AI70001B
  • yesbiotech/pAb Rabbit anti-Human FPRL-1 C-terminal/0.1 mg/AI70001B
商品介绍
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Description

Details

Description:Rabbit anti-human formyl peptide receptor-like 1(FPRL-1) C-terminal polyclonal antibody

Product Type:Purified polyclonal antibodies

Target Protein:Human formyl peptide receptor-like 1

Immunogen:A short peptide corresponding to the C-terminal amino acid sequence (SASPPAETELQAM) on FPRL1 was conjugated with KLH for immunization

Specificity:This polyclonal antibody reacts with the above mentioned peptide on ELISA plate and reacts with the 38KD FPRL1 on Western Blot.

Species Reacitvity:Human, others not tested

Source:Rabbit

Formulation:Lyophilized from a solution in 0.01M PBS pH7.2

Reconstitution:Double distilled water is recommended to reconstitute the antibody to 1mg/mL.

Storage:Store at -20oC

Research Area:G-protein coupled membrane receptor, chemotaxis and Alzheimer’s disease

Background:

Human formyl peptide receptor-like 1(FPRL-1) is a G-protein coupled seven transmembrane receptor. The receptor can bind to the formyl peptides derived from the degradation of the cell wall of infected bacteria and host cells. FPRL1 expressed on the cell surface of neutrophils and other leukocytes mediates the chemotaxis of these cells toward infected site. It has been reported that acute phase protein SAA is also a ligand of FPRL1 and SAA can induce the secretion of IL-8 and TNF-α by neutrophil through FPRL1 signalling. FPRL1 has also been shown to mediate the chemotaxis of microglia by Abeta42 peptide and the internalization of Abeta42 peptide into cytoplasma of macrophage, indicating that FRPL1 may participate in the Abeta42 peptide elicited pathogenesis in Alzheimer’s disease.

Application:

1. Western Blot:Fig 1: Analysis of HL60 cell extract using anti-FPRL1 pAb at 1:6,000 dilution.

2. Immunofluorescence:Analysis of HL-60 cells using 1:600 diluted fluorescence labelled anti-FPRL1 antibody (green). Nuclei have been labelled with PI (red).

References:

If research is published using this product, please inform Anogen in order to cite the reference on this datasheet. Anogen will provide one unit of product in the same category as gratitude.

Additional

Additional Information

Product SpecificitypAb Rabbit anti-Human FPRL-1 C-terminal
ApplicationWB, IF
Size0.1 mg
品牌介绍

Anogen-Yes Biotech Laboratories Ltd.是一家位于加拿大密西沙加的生物技术公司。成立于1989年,我们30年来一直是高质量抗体基产品的骄傲供应商。我们提供300多种单克隆和多克隆抗体,以及60多种类型的ELISA试剂盒,用于研究,诊断和治疗应用。


作为一家专注于研究的公司,我们还开发了许多专有的诊断和治疗产品。我们的产品Abcream是一种有效的抗牛皮癣局部抗IL-8(CXCL8)单克隆抗体,已于2001年获得中国国家食品药品监督管理局(SFDA)的批准,并获得多项国际专利。我们的用于诊断目的的新生儿TSH ELISA试剂盒也已获得加拿大卫生部的许可。我们还启动了针对炎症,阿尔茨海默氏病和癌症的研究和开发产品。


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