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yesbiotech/mAb anti-Thr181 Phosphorylated Tau, 1A4/0.1 mg/MO-M40099A

  • 产品编号: MO-M40099A
  • 美  元  价: $180.00
  • 市  场  价: ¥3600.00
  • 品       牌: yesbiotech
  • 产       地: 美国(厂家直采)
  • 公       司: yesbiotech
  • 产品分类: 分子类>核酸酶类>
  • 公司分类:
yesbiotech/mAb anti-Thr181 Phosphorylated Tau, 1A4/0.1 mg/MO-M40099A
  • yesbiotech/mAb anti-Thr181 Phosphorylated Tau, 1A4/0.1 mg/MO-M40099A
商品介绍
  • Description
  • Additional

Description

Details

Description:Mouse monoclonal antibody against Thr181 phosphorylated Tau protein

Purification:Protein G affinity purified

Product Type: Primary antibody

Target Protein:Human Thr181 phosphorylated Tau

Immunogen:KLH conjugated with a short peptide [Ala-Pro-Lys-Thr(p)-Pro-Pro-Ser-Ser-Gly-Glu-Cys], corresponding to the amino acid sequence 177-187 on the phosphorylated Tau protein.

Fusion Myeloma:Sp2/0-Ag14

Specificity:This antibody reacts with the unconjugated Thr181 phosphorylated Tau peptide.

Species Reacitvity:Human, mouse

Host / Isotype: Mouse, IgG2a Kappa

Formulation:Lyophilized from a solution in 0.01M PBS pH7.2

Reconstitution:Double distilled water is recommended to adjust the final concentration to 1.00mg/mL. Avoid repeated freeze and thaw cycle.

Storage: Store at -20oC

Research Area:Alzheimer’s disease and other neurodegenerative diseases

Background:

Tau is a highly soluble microtubule associated protein found in high concentration in neuron of central nervous system. The main function of the protein is stabilizing the microtubule in nerve fibre (axon). There are six tau isoforms which are formed by alternate splicing. Hyperphosphorylation of Tau protein results in aggregation and formation of neurofibrillary tangles, which is significantly associated with cognitive impairment in Alzheimer’s disease. Tau Thr181 phosphorylation has been used as a biomarker for the differentiation of Alzheimer’s disease and other primary dementia such as dementia with Lewy bodies..

Application:

1. Indirect ELISA: The antibody reacts with phosphorylated peptide [Ala-Pro-Lys-Thr(p)-Pro-Pro-Ser-Ser-Gly-Glu-Cys] coated ELISA plate in indirect ELISA. Cross-reactivity with un-phosphorylated peptide is very low.

2. Western Blot:The antibody detected a 46kD band in mouse brain tissue lysate.

Detect the mouse brain tissue lysates using antibody (Tau-pho181 1A4) at 1:2000 (0.5 μg/mL) dilution.

References:

If research is published using this product, please inform Anogen in order to cite the reference on this datasheet. Anogen will provide one unit of product in the same category as gratitude.

Additional

Additional Information

Product SpecificitymAb anti-Thr181 Phosphorylated Tau, 1A4
ApplicationEIA, WB
Size0.1 mg
品牌介绍

Anogen-Yes Biotech Laboratories Ltd.是一家位于加拿大密西沙加的生物技术公司。成立于1989年,我们30年来一直是高质量抗体基产品的骄傲供应商。我们提供300多种单克隆和多克隆抗体,以及60多种类型的ELISA试剂盒,用于研究,诊断和治疗应用。


作为一家专注于研究的公司,我们还开发了许多专有的诊断和治疗产品。我们的产品Abcream是一种有效的抗牛皮癣局部抗IL-8(CXCL8)单克隆抗体,已于2001年获得中国国家食品药品监督管理局(SFDA)的批准,并获得多项国际专利。我们的用于诊断目的的新生儿TSH ELISA试剂盒也已获得加拿大卫生部的许可。我们还启动了针对炎症,阿尔茨海默氏病和癌症的研究和开发产品。


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