Description:Mouse monoclonal antibody to human α-synuclein

Purification:Protein G affinity purified

Product Type: Primary antibody

Target Protein:Human α-synuclein

Immunogen:Recombinant human α-synuclein (1-140 aa) expressed in E. coli.

Fusion Myeloma:Sp2/0-Ag14

Specificity:This antibody recognizes human α-synuclein epitope (SEE)GYQDY.

Species Reacitvity:Human

Host / Isotype: Mouse, IgG1 Kappa

Formulation:Lyophilized from a solution in 0.01M PBS pH7.2

Reconstitution:Double distilled water is recommended to adjust the final concentration to 1.00mg/mL.

Storage: Store at -20^oC

Research Area:Parkinson’s disease, neurodegenerative diseases

Background:

α-synuclein is a protein of unknown function. It is mainly found in neural tissue. There is a lipid-binding motif similar to that of Apolipoproteins on its N-terminal. A hydrophobic region that is the non-beta component found in amyloid aggregation in Alzheimer’s disease is located at the central region of the protein. The abnormal aggregation of α-synuclein on brain tissue is called Lewy bodies, which are found in Parkinson’s disease, dementia and multiply system atrophy. Mutated α-synuclein gene is found to be associated with rare familial form of Parkinson’s disease.

Application:

ELISA: The antibody reacts with recombinant α-synuclein.

Western Blot:Detect recombinant α- synuclein (α-SYN) using antibody 4H11 at 5μg/mL dilution.

References:

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