Description:Mouse monoclonal antibody against N-terminal sequence of human amyloid beta peptides

Purification:Protein G affinity purified

Target Protein:N-terminal sequence of human beta amyloid peptide

Immunogen:N-terminal peptide (DAEFRHDS) of human beta amyloid peptides, conjugated with KLH

Fusion Myeloma:Sp2/0-Ag14

Specificity:This antibody recognizes the N-terminal peptide (DAEFRHDS) of human beta amyloid peptides and also reacts with full length Aβ40, Aβ42 and Aβ43.

Species Reacitvity:Human

Host / Isotype: Mouse, IgG1 Kappa

Formulation:Lyophilized from a solution in 0.01M PBS pH7.2

Reconstitution:Double distilled water is recommended to adjust the final concentration to 1.00mg/mL.

Storage: Store at -20^oC

Research Area:Aging and neurodegenerative diseases

Background:

Amyloid beta peptides Aβ42 and Aβ40 have been investigated extensively for predicating Alzheimer’s disease. A recent study on amyloid beta peptide Aβ43 in brain showed that Aβ43 is more fibrillogenic than other amyloid beta peptides and could be more useful as a biomarker or therapeutic target for Alzheimer’s disease.

Since Aβ40, Aβ42 and Aβ43 are different only at the few C-end amino acids, antibody to N-terminal sequence can bind with all three amyloid beta peptides.

Application:Immunohistochemistry,ELISA

References:

Y Zhang et al., Amyloid-β induces hepatic insulin resistance in vivo via JAK2. Diabetes (2013) 62, 4:1159-1166

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