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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
yesbiotech/mAb anti-Amyloid β Peptide 42, CA9 3F8/0.5 mg/MO-M40093D
产品编号:MO-M40093D
市  场 价:¥3600.00
场      地:美国(厂家直采)
产品分类: 蛋白类>多肽>多肽合成>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$180.00
品      牌: yesbiotech
公      司:yesbiotech
公司分类:
yesbiotech/mAb anti-Amyloid β Peptide 42, CA9 3F8/0.5 mg/MO-M40093D
商品介绍
  • Description
  • Additional

Description

Details

Description:Mouse monoclonal antibody to C-terminal of amyloid beta peptide 42 (Aβ42)

Purification:Protein G affinity purified

Product Type:Primary antibody

Target Protein:C-terminal of amyloid beta peptide 42

Immunogen:KLH conjugated to a short peptide (MVGGVVIA) with amino acid sequence corresponding to the C-terminal of Aβ42

Fusion Myeloma:Sp2/0-Ag14

Specificity:This antibody recognizes the C-terminal sequence (MVGGVVIA) of Aβ42 and full length Aβ42.

Cross-Reactivity:The antibody showed very weak to none cross-reactivity with full length Aβ43 and Aβ40 in indirect ELISA.

Species Reactivity:Human and other primates; mouse, rat

Host / Isotype:Mouse, IgG2b Kappa

Formulation:Lyophilized from a solution in 0.01M PBS pH7.2

Reconstitution:Double distilled water is recommended to adjust the final concentration to 1.00 mg/mL.

Storage: Store at -20oC

Research Area:Aging and neurodegenerative diseases

Background:

Amyloid beta peptide 42 (Aβ42) is best known for its role in the formation of senile plaques in the brain of patients with Alzheimer’s disease. Aβ42 and Aβ40 are the two major amyloid peptides that are produced after cleavage of amyloid precursor protein by secretases. Aβ42 (42 amino acids) is very fibrillogenic. The beta pleated structure of Aβ42 constituents the initial and key component of the insoluble amyloid fibril in senile plaque. It is widely accepted that Aβ42 contributes to the pathogenesis of Alzheimer’s disease. One proposition is that the deposition of amyloid fibril onto the brain tissue results in Alzheimer’s disease. Another is that the neurotoxicity of Aβ42 oligomer is the cause of the disease.

Application:

IHC:The picture below shows the 40x amplified brain tissue section from transgenic Alzheimer’s disease mouse model after IHC staining with clone CA9 3F8.

(Procedure: After heat induced epitope retrieval, formalin-fixed paraffin-embedded brain tissue section from 12 month old APPswe/PSEN1dE9 mouse was incubated at 4oC with 0.01mg/ml CA9 3F8 overnight. Bound antibody was detected using a HRP-labeled goat anti-mouse antibody.)

References:

If research is published using this product, please inform Anogen in order to cite the reference on this datasheet. Anogen will provide one unit of product in the same category as gratitude.

Additional

Additional Information

Product SpecificitymAb anti-Amyloid β Peptide 42, CA9 3F8
ApplicationIHC
Size0.5 mg
品牌介绍

Anogen-Yes Biotech Laboratories Ltd.是一家位于加拿大密西沙加的生物技术公司。成立于1989年,我们30年来一直是高质量抗体基产品的骄傲供应商。我们提供300多种单克隆和多克隆抗体,以及60多种类型的ELISA试剂盒,用于研究,诊断和治疗应用。


作为一家专注于研究的公司,我们还开发了许多专有的诊断和治疗产品。我们的产品Abcream是一种有效的抗牛皮癣局部抗IL-8(CXCL8)单克隆抗体,已于2001年获得中国国家食品药品监督管理局(SFDA)的批准,并获得多项国际专利。我们的用于诊断目的的新生儿TSH ELISA试剂盒也已获得加拿大卫生部的许可。我们还启动了针对炎症,阿尔茨海默氏病和癌症的研究和开发产品。


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