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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
yesbiotech/mAb anti Human PD-L1, clone 6A5/0.1 mg/MO-L40044E
产品编号:MO-L40044E
市  场 价:¥4000.00
场      地:美国(厂家直采)
产品分类: 蛋白类>多肽>多肽合成>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$200.00
品      牌: yesbiotech
公      司:yesbiotech
公司分类:
yesbiotech/mAb anti Human PD-L1, clone 6A5/0.1 mg/MO-L40044E
商品介绍
  • Description
  • Additional

Description

Details

Description:Mouse monoclonal antibody (mAb) to human programmed death- ligand 1 (PD-L1), or mouse mAb to B7H1, or mouse mAb to human CD274.

Purification: Protein G affinity purified

Target Protein:Human programmed death-ligand 1 (PD-L1), also known as B7H1 or CD274.

Immunogen:Human cell expressed recombinant PD-L1 (Phe19-Arg238) with poly-histidine tag at C-terminus.

Fusion Myeloma:SP2/0

Specificity:Reactive with human programmed death- ligand 1 (PD-L1).

Species Reactivity:Human, others not tested.

Host / Isotype: Mouse, IgG1 Kappa

Formulation:Lyophilized from a solution in 0.01M PBS, pH 7.0

Reconstitution:Double distilled water is recommended to reconstitute the antibody to 1mg/mL.

Storage: Store at -20oC

Research Area:Immunosuppression. Cancer immunotherapy.

Background:

Programmed Death-Ligand 1 (PD-L1), a 40KD transmembrane protein, is a ligand of immune checkpoint protein Programmed Death-1 (PD-1). During T-cell receptor signalling, the binding of PD-L1 to PD-1 transmits an inhibitory signal to activated T-cells to decrease their proliferation. PD-L1 is also believed to play a role in the generation and regulation of Treg cells, and in the enhancement of Treg cell function. PD-L1/PD-1 pathway is important to immune suppression, such as self-tolerance, suppression of immune-rejection during pregnancy and allograft, and immune evasion by cancers. Upregulation of PD-L1 has been found to be associated with many cancer types. For example, increased PD-L1 expression has been shown to be related to tumor aggressiveness and higher mortality in patients with renal cell carcinoma, and related to significantly poorer prognosis and lower intraepithelial CD8+ T-lymphocyte count in patience with ovarian cancer. Antibodies that block the PD-L1 /PD-1 pathway have been extensively studied in clinical trials, and some have been approved as immunotherapy for cancer.

Applications:

ELISA:Indirect ELISA: The antibody reacts with recombinant PD-L1 in indirect ELISA.

Western blot:Western Blot: Anti-PD-L1 clone 6A5 detected 40ng recombinant PDL-1 on Western Blot. The blot was stained with HRP substrate 4-Chloro-1-Naphthol.

References:

If research is published using this product, please inform Anogen in order to cite the reference on this datasheet. Anogen will provide one unit of product in the same category as gratitude.

Additional

Additional Information

Product SpecificitymAb anti Human PD-L1/B7H1/CD274, 6A5
ApplicationEIA, WB
Size0.1 mg
品牌介绍

Anogen-Yes Biotech Laboratories Ltd.是一家位于加拿大密西沙加的生物技术公司。成立于1989年,我们30年来一直是高质量抗体基产品的骄傲供应商。我们提供300多种单克隆和多克隆抗体,以及60多种类型的ELISA试剂盒,用于研究,诊断和治疗应用。


作为一家专注于研究的公司,我们还开发了许多专有的诊断和治疗产品。我们的产品Abcream是一种有效的抗牛皮癣局部抗IL-8(CXCL8)单克隆抗体,已于2001年获得中国国家食品药品监督管理局(SFDA)的批准,并获得多项国际专利。我们的用于诊断目的的新生儿TSH ELISA试剂盒也已获得加拿大卫生部的许可。我们还启动了针对炎症,阿尔茨海默氏病和癌症的研究和开发产品。


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